Education:
1994-2000: Ph.D (Cell Biology), Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai, China
1987-1991: BA (Plant Physiology and Biochemistry), Department of Biology, Nankai University, Tianjin, China
Professional experiences:
2021- Professor, School of Life Sciences, Chongqing University, Chongqing, China
2014-2021 PI (tenure track), Health Sciences Research Center, Peking University, Bejing, China
2003-2013 Associate Research Scientist, Institute for Cancer Genetics,Columbia University, New York, USA
2001-2003 Postdoctoral Fellow, Department of Pathology, Weill Medical College, Cornell University, New York, USA
2000-2001 Postdoctoral Fellow, Department of Molecular Biochemistry and Biophysics, Medical School, Yale University, New Haven, USA
1991-994 Technician, Department of Genetics, Nankai University, Tianjin, China
Courses
Biochemistry, Molecular Cell Biology, Basic techniques of Molecular Biology
Major achievement
1. Fangzhou Li, Qianqian Sun, Kun Liu, Ning Lin, Kaiqiang You, Mingwei Liu, Ning Kon, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Jun Qin, Wei Gu, Dawei Li, Wenhui Zhao. (2020). OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via the deubiquitination activity. Nature Communications. 2020 Aug 21;11(1):4184. doi: 10.1038/s41467-020-17926-7.（Corresponding author）
2. Xue, Junhui; Cao, Zhengyi; Cheng, Yuning; Wang, Jiyin; Liu, Yujuan; Yang, Ruixiang; Li, Hui; Jiang, Wei; Li, Gang; Zhao, Wenhui; Zhang, Xiaowei.(2020).Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression.Cancer Letters, 2020, 471: 12-26. doi:10.1016/j.canlet.2019.11.043
3. Fangzhou Li, Qianqian Sun, Kun Liu, Haichao Han, Ning Lin, Zhongyi Cheng, Yueming Cai, Feng Tian, Zebin Mao, Tanjun Tong, Wenhui Zhao. (2019). The deubiquitinase OTUD5 regulates Ku80 removal and non-homologous end joining. Cell Mol Life Sci. 2019 Oct;76(19):3861-3873. doi: 10.1007/s00018-019-03094-5. （Corresponding author）
4. Li F, Han H, Sun Q, Liu K, Lin N, Xu C, Zhao Z, Zhao W. (2019). USP28 regulates deubiquitination of histone H2A and cell proliferation. Exp Cell Res. 2019 Jun 1;379(1):11-18. doi: 10.1016/j.yexcr.2019.03.026. （Corresponding author)
5. Kun Liu, Fangzhou Li, Qianqian Sun, Ning Lin, Haichao Han, Kaiqiang You, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Meiyu Geng, Yingming Zhao, Wei Gu, Wenhui Zhao. (2019). p53 β-hydroxybutyrylation attenuates p53 activity. Cell Death & Disease. 2019 Mar 11;10(3):243. doi:10.1038/s41419-019-1463-y. （Corresponding author）
6. Huang H, Luo Z, Qi S, Huang J, Xu P, Wang X, Gao L, Li F, Wang J, Zhao W, Gu W, Chen Z, Dai L, Dai J, Zhao Y. (2018). Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 28(1):111-125. doi: 10.1038/cr.2017.149.
7. Nan Xie, Liwei Ma, Feng Zhu, Wenhui Zhao, Feng Tian, Fuwen Yuan, Jingxuan Fu, Daoyuan Huang, Cuicui Lv & Tanjun Tong. (2016). Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress. Scientific Reports 6:36171. doi:10.1038/srep36171
8. Liu K, Li F, Han H, Chen Y, Mao Z, Luo J, Zhao Y, Zheng B, Gu W, Zhao W. (2016). Parkin regulates the activity of pyruvate kinase M2. J Biol Chem. 291(19):10307-17. doi: 10.1074/jbc.M115.703066. （Corresponding author）
9. Yu M, Liu K, Mao Z, Luo J, Gu W, Zhao W. (2016). USP11 is a negative regulator to γH2AX ubiquitylation by RNF8/RNF168. J Biol Chem. 291(2):959-67. doi: 10.1074/jbc.M114.624478. （Corresponding author）
9. Yu M, Liu K, Mao Z, Luo J, Gu W, Zhao W. (2016). USP11 is a negative regulator to γH2AX ubiquitylation by RNF8/RNF168. J Biol Chem. 291(2):959-67. doi: 10.1074/jbc.M114.624478. （Corresponding author）
10. Li Qiang, Ning Kon, Wenhui Zhao, Ning Kon, Colette M. Knight, Carrie Welch, Utpal Pajvani, Wei Gu, and Domenico Accili. (2015). Hepatic SirT1-dependent gain of function of stearoyl-CoA desaturase-1 conveys dysmetabolic and tumor progression functions. Cell Reports 11, 1–12. doi: 10.1016/j.celrep.2015.05.025
11. Li Qiang, Liheng Wang, Ning Kon, Wenhui Zhao, Sangkyu Lee, Yiying Zhang, Michael Rosenbaum, Yingming Zhao, Wei Gu, Stephen R. Farmer, and Domenico Accili. (2012). Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PPARg. Cell 150, 620–632. doi:10.1016/j.cell.2012.06.027
12. Yue Chen, Wenhui Zhao, Jeong Soo Yang, Zhongyi Cheng, HaoLuo, Zhike Lu, Minjia Tan, Wei Gu, and Yingming Zhao. (2012). Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Molecular & Cellular Proteomics. 11(10):1048-62. doi: 10.1074/mcp.M112.01954713.
13. Scortegagna M, Subtil T, Qi J, Kim H, Zhao Wenhui, Gu Wei, Kluger H, Ronai ZA. (2011). USP13 enzyme regulates Siah2 ligase stability and activity via noncatlytic ubiquitin-binding domains. J Biol Chem. 286(31):27333-41. doi: 10.1074/jbc.M111.218214
14. Jing Shan, Wenhui Zhao, and Wei Gu. (2009). Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol. Cell 36, 469-476. doi:10.1016/j.molcel.2009.10.018
15. Wenhui Zhao, Jan-Philipp Kruse, Yi Tang, Sung Yun Jung, Jun Qin, Wei Gu. (2008). Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451, 587-590. doi:10.1038/nature06515.
16. Yi Tang, Wenhui Zhao, Yue Chen, Yingming Zhao and Wei Gu. (2008). Acetylation is indispensable for p53 activation. Cell 133, 612-626. doi: 10.1016/j.cell.2008.03.025
17. Abida WM, Nikolaev A, Wenhui Zhao, Zhang W, Gu W. (2007). Fbxo11 promotes the neddylation of p53 and inhibits its transcriptional activity. J Biol Chem. 282, 1797-804. doi:10.1074/jbc.M609001200
Contact information
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