Haibo Wu

2018.07-now     Professor/Principal Investigator, Chongqing University
2015.07-2018.06  Associate Professor, Northwest A&F University

I am curious about the basic scientific questions related to the field of life sciences and try to answer/uncover them with cell biology, biochemistry and molecular biology techniques. Since becoming a scientific researcher in 2009, my works include immunity, microbiology, embryonic development, genetic engineering, cancer, et al. Recent years, my research focuses on the immune response in macrophages during infection. I mainly study the interaction between pathogenic microorganisms and host, and identify the pathogenic/host factors closely related to the pathogenesis.
As a researcher, I have published more than 40 journal articles in internationally recognized top tier journals as first author, co-author and corresponding author. Some of the journals where I have published in are Cell Host & Microbe (WoS Q1, IF=31.32), Nature Microbiology (WoS Q1, IF=30.96), Proc. Natl Acad. Sci. USA (WoS Q1, IF=12.78), Genome Biology (WoS Q1, IF=17.91), EMBO Reports (WoS Q1, IF= 9.07), PLoS Pathogens (WoS Q1, IF= 7.46), and mBio (WoS Q1, IF= 7.79).

Cell Biology, Experimental Zoology

Serve as a member of Editorial Board (Review Editor) for Frontiers in Drug Discovery.
Committee member of the Collaborative Group of Multidisciplinary Diagnosis of Cancer (MDD), Committee of Tumor Biomarker, China Anti Cancer Association;
Committee member of Tumor Informatics, Chongqing Bioinformatics Society;
Committee member of Chongqing Society for Microbiology;
Committee member of Chongqing Society for Cell biology.
Serve as reviewer for tens of peer-reviewed journals, such as Nat Commun, Ageing Res Rev, Cell Mol Life Sci, PLoS Genet, Cell Death Dis, JBC, JVI.

Selected Papers (First or Corresponding author)
1. Wu H, Xing N, Meng K, Fu B, Xue W, Dong P, Tang W, Xiao Y, Liu G, Luo H, Zhu W, Lin X, Meng G, Zhu Z, Nucleocapsid Mutations R203K/G204R Increase the Infectivity, Fitness and Virulence of SARS-CoV-2. Cell Host & Microbe. 2021;29(12):1788-1801.e6
2. Wu H, Wang Y, Zhang Y, Yang M, Lv J, Liu J, and Zhang Y. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. PNAS. 2015, Mar 31; 112(13): E1530–E1539. (Featured article, highlighted by Christopher K. Tuggle, PNAS, 2015)
3. Gao Y, Wu H, Wang Y, Liu X, Chen L, Li Q, Cui C, Liu X, Zhang J, Zhang Y. Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biology. 2017,18(1): 13.(Co-first author)
4. Fu B, Lin X, Tan S, Zhang R, Xue W, Zhang H, Zhang S, Zhao Q, Wang Y, Feldman K, Shi L, Zhang S, Nian W, Pavani K, Li Z, Wang X, Wu H. MiR-342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death. EMBO Rep. 2021 Sep 6;22(9):e52252.
5. Fu B, Xue W, Zhang H, Zhang R, Feldman K, Zhao Q, Zhang S, Shi L, Pavani KC, Nian W, Lin X, Wu H. MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling. mBio. 2020, 11:e00557-20.
6. Lin X, Fu B, Yin S, Li Z, Liu H, Zhang H, Xing N, Wang Y, Xue W, Xiong Y, Zhang S, Zhao Q, Xu S, Zhang J, Wang P, Nian W, Wang X, Wu H. ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. iScience. 2021 Apr 23;24(4):102293.
7. Lin X, Fu B, Xiong Y, Xing N, Xue W, Guo D, Zaky M, Pavani K, Kunec D, Trimpert J, Wu H. Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection. PLoS Pathogens. 2023 Jan 23;19(1):e1011128.

1. Chongqing Talents: Exceptional Young Talents Project (2020)
2. Young Talent Fund of University Association for Science and Technology in Shaanxi, China (2017)
3. Excellent Doctoral Dissertation of Shaanxi Province (2017)
3. Shaanxi Province Scientific and Technological Award, Grade of Award: First prize (2016)

There are 3 postdoctoral fellows, 4 doctoral candidates and 6 master candidates in my group.

Email: hbwu023{at}cqu.edu.cn