EDUCATION:
1. 2003.9- 2008.7 Ph.D，Tsinghua University, Molecular and Cellular Biology
2. 1998.9-2001.7 Master，Chinese Academy of Agricultural sciences, Biochemistry
3. 1994.9-1998.7 Bachelor, China Agricultural University, Animal genetics
Working experience
1. 2014 – present, Professor, Chongqing University, School of Life Sciences
2. 2012 – 2014, Research Assistant Professor, Northwestern University, Chicago, Dept. of Pathology, Feinberg School of Medicine
3. 2010-2011, Research Associate Postdoc fellow, Northwestern University, Chicago, Feinberg School of Medicine
4. 2009, Postdoc fellow, University of Chicago, Chicago, Ben May Department for Cancer Research
5. 2008, Postdoc fellow, University of Pittsburgh, Pennsylvania, University of Pittsburgh Cancer Institute
Research interests
Our lab aims to investigate the basic and translational aspects of human cancers, with a focus on cancer-related signaling pathways, tumor microenvironment and cancer therapy. We have established multi-disciplinary cancer research programs in cellular, biochemical, post-translational and basic research as well as investigations of cancer control and medicine.
Courses
Molecular and Cellular Biology, Animal Physiology
Academic position
No.
Major achievement
1)Cheng Zeng, Tingting Zou, Junyan Qu, Xu Chen, Suping Zhang*, Zhenghong Lin*. Cyclovirobuxine D Induced-Mitophagy through the p65/BNIP3/LC3 Axis Potentiates Its Apoptosis-Inducing Effects in Lung Cancer Cells. International journal of Molecular Science. 2021 May 29;22(11):5820.
2)Tingting Zou, Zhenghong Lin*. The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression. International journal of Molecular Science. 2021 May 27;22(11):5754.
3)Junyan Qu, Cheng Zeng, Tingting Zou, Xu Chen, Xiaolong Yang*, Zhenghong Lin*. Autophagy Induction by Trichodermic Acid Attenuates Endoplasmic Reticulum Stress-Mediated Apoptosis in Colon Cancer Cells. International journal of Molecular Science. 2021 May 25;22(11):5566.
4) Junyan Qu #, Tingting Zou#, Zhenghong Lin*. The Roles of the Ubiquitin-Proteasome System in the Endoplasmic Reticulum Stress Pathway. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1526.
5) Youbo Zhao, Menghuan Li, Xuemei Yao, Yang Fei, Zhenghong Lin, Zhengguo Li, Kaiyong Cai, Yanli Zhao, Zhong Luo. HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications. Cell Reports. 2020 Dec 8;33(10):108487.
6）Le Yu, Ling Dong, Hui Li, Zhaojian Liu, Zhong Luo, GuangjieDuan, Xiaotian Dai*, and Zhenghong Lin*. Ubiquitination-mediated Degradation of SIRT1 by SMURF2 Suppresses CRC Cell Proliferation and Tumorigenesis. Oncogene, 2020 May;39(22):4450-4464.
7）Ling Dong#, Le Yu#, Hui Li, Lei Shi, Zhong Luo, Huakan Zhao, Zhaojian Liu, Guobing Yin, Xiaohua Yan*, and Zhenghong Lin*. An NAD+-dependent deacetylase SIRT7 promotes HCC development through deacetylation of USP39. iScience. 2020 Aug 21;23(8):101351.
8）Liu Liu#, Le Yu#, Cheng Zeng, # Hua Long, GuangjieDuan, Guobing Yin, Xiaotian Dai*, and Zhenghong Lin*. The E3 ubiquitin ligase HRD1 promotes lung tumorigenesis by promoting sirtuin 2 ubiquitination and degradation. Molecular and Cellular Biology, 2020 Mar 16;40(7):e00257-19.
9）Le Yu#, Ling Dong#, Yang Wang, Liu Liu, Hua Long, Hui Li, Jinping Li, Xiaolong Yang, Zhaojian Liu, GuangjieDuan, Xiaotian Dai, Zhenghong Lin*. Reversible Regulation of SATB Ubiquitination by USP47 and SMURF2 Mediates Colon Cancer Cell Proliferation and Tumor Progression. Cancer Letters, 2019 Apr 28;448:40-51.
10) Liu Liu, Hua Long, Yan Wu, Hui Li, Ling Dong, Li Zhong, Zhaojian Liu, Xiaolong Yang, Xiaotian Dai, Lei Shi, Maozhi Ren, Zhenghong Lin*. HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression. Cellular Signaling. 2018 Oct;50:90-99.
11)Shumin Zhang, Sen Liu, Jiankui Zhang, Russel J Reiter, Ying Wang, Dan Qiu, Xiumei Luo, A Rehman Khalid, Hanyan Wang, Li Feng, Zhenghong Lin, Maozhi Ren. Synergistic anti-oomycete effect of melatonin with a biofungicide against oomycetic black shank disease. Journal of Pineal Research. 2018 Sep;65(2):e12492.
12)Ting Zhao, Lu-Lin Xu, Yan Zhang, Zheng-Hong Lin, Tao Xia, Deng-Feng Yang, Ye-Miao Chen, Xiao-Long Yang. Three new α-pyrone derivatives from the plant endophytic fungus Penicillium ochrochloronthe and their antibacterial, antifungal, and cytotoxic activities. J Asian Nat Prod Res. 2018 Aug 21:1-8.
13) Ling Dong; Le Yu; Chunrong Bai; Liu Liu; Hua Long; Lei Shi; Zhenghong Lin*. USP27-mediated Cyclin E Stabilization Drives Cell Cycle Progression and Hepatocellular Tumorigenesis. Oncogene. 2018 May; 37(20):2702-2713.
14)Lei Shi*; Lihua Yu; Fagui Zou; Huimin Hu; Kun Liu; Zhenghong Lin*. Gene expression profiling and functional analysis reveals that p53 pathway-related gene expression is highly activated in cancer cells treated by cold atmosphe c plasma-activated medium. Peer J, 2017 Aug, 5: e3751.
15)Yuqiong Wang; Xiyu Zhang; Wei Tang; Zhenghong Lin; Limei Xu; Ruifen Dong; Yiluo Li; Jieyin Li; Zaixin Zhang; Xiangzhi Li; Ling Zhao; Jian-jun Wei; Changshun Shao; Beihua Kong; Zhaojian Liu. miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma. Cell Death Differ, 2017 Dec, 24(12): 2089~2100.
16)Yan Wu，Chunxiang Bian，Chunlin Zhen，Liu Liu，Zhenghong Lin，Muhammad Farrukh Nisar，Mei Wang，Joerg W.Bartsch，Enyi Huang，Ping Ji，Li Yang，Yanhong Yu，Junfeng Yang，Xuemei Jiang，Julia Li Zhong,*. Telomerase reverse transcriptase mediates EMT through NF-kappa B signaling in tongue squamous cell carcinoma. Oncotarget，2017.10.17，8（49）：85492~85503; 8.
17) Xuebao Zhang，Juan Cai，Ze Zheng，Lisa Polin，Zhenghong Lin，Aditya Dandekar，Li Li，Fei Sun，Russell L Finley Jr，Deyu Fang，Zeng-Quan Yang，Kezhong Zhang*. A novel ER–microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression. Cell Discovery，2015.9.8，1：15024
18)Sinyi Kong，Hongxin Dong，Jianxun Song，Muthusamy Thiruppathi，Bellur S.Prabhakar，Quan Qiu, Zhenghong Lin，Chini, Eduardo，Bin Zhang，Deyu Fang. Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKK alpha Phosphorylation. J Immunol.，2015.10.15，195（8）：3685~3693.
19)Zhenghong Lin; Can Tan; Quan Qiu; Sinyi Kong; Heeyoung Yang; Fang Zhao; Zhaojian Liu; Jinping Li; Qingfei Kong; Beixue Gao; Terry Barrett; Guang-Yu Yang; Jianing Zhang; Deyu Fang*. Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1. Cell Discovery, 2015 Apr, 1: 15028
20)Heeyoung Yang, Quan Qiu, Beixue Gao, Sinyi Kong, Zhenghong Lin and Deyu Fang. Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation. J Exp Med. 2014 Nov 3.
21)Sinyi Kong, Muthusamy Thiruppathi, Quan Qiu, Zhenghong Lin, Hongxin Dong, Bellur S. Prabhakar, Eduardo Nunes Chini and Deyu Fang. DBC1 Is a Suppressor of B Cell Activation by Negatively Regulating Alternative NF-кB Transcriptional Activity. J Immunol. 2014 Oct 31.
22)Zhenghong Lin, Heeyoung Yang, Can Tan, Jinping Li, Zhaojian Liu, Qiu Quan, Sinyi Kong, Junsheng Ye, Beixue Gao and Deyu Fang. The Deubiquitinase USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation. Cell Reports. 2013 Dec 11.
23)Kyeorda L. Kemp, Zhenghong Lin, Fang Zhao, Beixue Gao, Jianxun Song, Kezhong Zhang and Deyu Fang. The serine-threonine kinase Inositol-requiring enzyme 1 α (IRE1α) promotes IL-4 production in T helper cells. J Biol Chem. 2013 Nov 15;288(46):33272-82.
24) Quan Qiu, Ze Zheng, Lin Chang, Yuan-Si Zhao, Can Tan, Aditya Dandekar, Zheng Zhang, Zhenghong Lin, Ming Gui, Xiu Li, Tongshuai Zhang, Qingfei Kong, Hulun Li, Sha Chen, An Chen, Randal J Kaufman, Wei-Lei Yang, Hui-Kuan Lin, Donna Zhang, Harris Perlman, Edward Thorp, Kezhong Zhang, and Deyu Fang.Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J. 2013 Aug 13.
25) Po-Han Chen, Xiaoyan Chen, Zhenghong Lin, Deyu Fang, and Xiaolin He.The structural basis of R-spondin recognition by LGR5 and RNF43. Genes & Development. 2013 Jun 11.
26) Zhenghong Lin and Deyu Fang. The roles of SIRT1 in cancer. Genes Cancer. 2013 Mar;4(3-4):97-104.
27) Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D. Zhang, and Deyu Fang. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppresscell apoptosis and is required for mouse embryonic development. Molecular Cell. 2012 May 25;46(4):484-94.
28)Xiaohua Yan#, Zhenghong Lin#, Feng Chen, Xingang Zhao, Hua Chen, Yuanheng Ning, and Ye-Guang Chen.Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem. 2009 Oct 30;284(44):30097-104. (co-first author)
29)Zhenghong Lin, Chan Gao, Yuanheng Ning, Xi He, Wei Wu, and Ye-Guang Chen. The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. J Biol Chem.2008 Nov 28;283(48):33053-8.
30)YIN Chang-Cheng; WANG Shang-Zi; LIN Zheng-Hong; WANG Xiang-Bin; LIU Jing; HUANG Hua-Liang. An efficient approach to the synthesis of a high-quality random peptide repertoire. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003.10, 35(10): 921~924; (SCI)
Awards
1.Topic guest editor of Frontiers in Cell and Developmental Biology
2.Invited reviewers of Cancer Letters, Cellular and Molecular Life Sciences, Protein & Cell，Cell Death and Disease, Journal of Translational Medicine, Genome Instability & Disease, PLOS ONE，Life Science，Journal of Molecular Biology, etc.
3.Member of Chinese Society for Cell Biology
4.Member of Cancer Metabolism Committee in China
5.Member of Chongqing Nutrition Association
Postgraduate training
Master, PhD or postdoctoral positions are available in our lab. The positions are for qualified candidates who wish to pursue a career in cancer research. The ideal candidates for PhD or postdoctoral positions should demonstrate strong experience in cancer biology, medicine, pathology, molecular biology, and/or biochemistry. Experience in working with mouse models is extremely desirable but not necessary. To apply, please send cover letter, curriculum vitae (via email) to: zhenghonglin@cqu.edu.cn
Contact information
contact information: zhenghonglin@cqu.edu.cn
