姓 名：赵文会

湖北人，理学博士，重庆大学9001诚信金沙9001cc教授。1987年进入南开大学生物系，获得理学学士（1991）；1994年进入中国科学院上海细胞所（硕博连读），获得理学博士学位（2000）。

• 1987.09—1991.07 南开大学生物系   理学学士

• 1994.09—2000.07 中国科学院上海细胞所  理学博士（硕博连读）

• 1991.09—1994.09 南开大学生物系  实验员

• 2000.09—2001.10 Depart. MBB, Medical School, Yale University   Postdoc

• 2001.10—2003.07 Weill Medical College, Corenll University   Postdoc

• 2003.07—2008.01 Institute for Cancer Genetics, Columbia University   Postdoc

• 2008.01—2013.12 Columbia University, Institute for Cancer Genetics  Associate Scientist

• 2014.01—2020.12 北京大学医学部, 生物化学与分子生物学系 研究员

• 2021.02 至 今 重庆大学9001诚信金沙9001cc 教授

分子细胞生物学

1. Fangzhou Li, Qianqian Sun, Kun Liu, Ning Lin, Kaiqiang You, Mingwei Liu, Ning Kon, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Jun Qin, Wei Gu, Dawei Li, Wenhui Zhao. (2020). OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via the deubiquitination activity. Nature Communications. 2020 Aug 21;11(1):4184. doi: 10.1038/s41467-020-17926-7.（通讯作者）  

2. Xue, Junhui; Cao, Zhengyi; Cheng, Yuning; Wang, Jiyin; Liu, Yujuan; Yang, Ruixiang; Li, Hui; Jiang, Wei; Li, Gang; Zhao, Wenhui; Zhang, Xiaowei.(2020).Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression.Cancer Letters, 2020, 471: 12-26.  doi:10.1016/j.canlet.2019.11.043  

3. Fangzhou Li, Qianqian Sun, Kun Liu, Haichao Han, Ning Lin, Zhongyi Cheng, Yueming Cai, Feng Tian, Zebin Mao, Tanjun Tong, Wenhui Zhao. (2019). The deubiquitinase OTUD5 regulates Ku80 removal and non-homologous end joining. Cell Mol Life Sci. 2019 Oct;76(19):3861-3873. doi: 10.1007/s00018-019-03094-5. （通讯作者）  

4. Li F, Han H, Sun Q, Liu K, Lin N, Xu C, Zhao Z, Zhao W. (2019). USP28 regulates deubiquitination of histone H2A and cell proliferation. Exp Cell Res. 2019 Jun 1;379(1):11-18. doi: 10.1016/j.yexcr.2019.03.026. （通讯作者）  

5. Kun Liu, Fangzhou Li, Qianqian Sun, Ning Lin, Haichao Han,  Kaiqiang You, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong,  Meiyu Geng, Yingming Zhao, Wei Gu, Wenhui Zhao. (2019). p53 β-hydroxybutyrylation attenuates p53 activity. Cell Death & Disease. 2019 Mar 11;10(3):243. doi:10.1038/s41419-019-1463-y. （通讯作者）  

6. Huang H, Luo Z, Qi S, Huang J, Xu P, Wang X, Gao L, Li F, Wang J, Zhao W, Gu W, Chen Z, Dai L, Dai J, Zhao Y. (2018). Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 28(1):111-125. doi: 10.1038/cr.2017.149.  

7. Nan Xie, Liwei Ma, Feng Zhu, Wenhui Zhao, Feng Tian, Fuwen Yuan, Jingxuan Fu, Daoyuan Huang, Cuicui Lv & Tanjun Tong. (2016). Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress. Scientific Reports 6:36171. doi:10.1038/srep36171  

8. Liu K, Li F, Han H, Chen Y, Mao Z, Luo J, Zhao Y, Zheng B, Gu W, Zhao W. (2016). Parkin regulates the activity of pyruvate kinase M2. J Biol Chem. 291(19):10307-17. doi: 10.1074/jbc.M115.703066. （通讯作者）  

9. Yu M, Liu K, Mao Z, Luo J, Gu W, Zhao W. (2016). USP11 is a negative regulator to γH2AX ubiquitylation by RNF8/RNF168. J Biol Chem. 291(2):959-67. doi: 10.1074/jbc.M114.624478. （通讯作者）  

10. Li Qiang, Ning Kon, Wenhui Zhao, Ning Kon, Colette M. Knight, Carrie Welch, Utpal Pajvani, Wei Gu, and Domenico Accili. (2015). Hepatic SirT1-dependent gain of function of stearoyl-CoA desaturase-1 conveys dysmetabolic and tumor progression functions. Cell Reports 11, 1–12. doi: 10.1016/j.celrep.2015.05.025  

11.  Li Qiang, Liheng Wang, Ning Kon, Wenhui Zhao, Sangkyu Lee, Yiying Zhang, Michael Rosenbaum, Yingming Zhao, Wei Gu, Stephen R. Farmer, and Domenico Accili. (2012). Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PPARg. Cell 150, 620–632. doi:10.1016/j.cell.2012.06.027  

12. Yue Chen, Wenhui Zhao, Jeong Soo Yang, Zhongyi Cheng, HaoLuo, Zhike Lu, Minjia Tan, Wei Gu, and Yingming Zhao. (2012). Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Molecular & Cellular Proteomics. 11(10):1048-62. doi: 10.1074/mcp.M112.019547  

13. Scortegagna M, Subtil T, Qi J, Kim H, Zhao Wenhui, Gu Wei, Kluger H, Ronai ZA. (2011). USP13 enzyme regulates Siah2 ligase stability and activity via noncatlytic ubiquitin-binding domains. J Biol Chem. 286(31):27333-41. doi: 10.1074/jbc.M111.218214  

14. Jing Shan, Wenhui Zhao, and Wei Gu. (2009). Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol. Cell 36, 469-476. doi:10.1016/j.molcel.2009.10.018  

15. Wenhui Zhao, Jan-Philipp Kruse, Yi Tang, Sung Yun Jung, Jun Qin, Wei Gu. (2008). Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451, 587-590.  doi:10.1038/nature06515. （第一作者）  

16. Yi Tang, Wenhui Zhao, Yue Chen, Yingming Zhao and Wei Gu. (2008). Acetylation is indispensable for p53 activation. Cell 133, 612-626. doi: 10.1016/j.cell.2008.03.025  

17. Abida WM, Nikolaev A, Wenhui Zhao, Zhang W, Gu W. (2007). Fbxo11 promotes the neddylation of p53 and inhibits its transcriptional activity. J Biol Chem. 282, 1797-804. doi:10.1074/jbc.M609001200

本科生：

生物化学，蛋白质化学生物学，生物化学实验

研究生：

生物化学实验，分子生物学基础，生物大分子结构与功能

生物医学