EDUCATION
2007-2013 Ph.D. in Biochemistry and Molecular biology, State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
2003-2007 B.S. in Biology, College of Biotechnology, Southwest University,Chongqing, China.
EMPLOYMENT
2019-2020 Visiting Scholar, Life Science Center for Survival Dynamics, University of Tsukuba, Tsukuba, Japan
2016-present Associate Professor, School of Life Sciences, Chongqing University, Chongqing, China.
2015-2016 Assistant Professor, School of Life Sciences, Chongqing University, Chongqing, China.
2013-2015 Postdoc, School of Life Sciences, Chongqing University, Chongqing, China.
Research interests
The pulse of the molting hormone (ecdysteroid) is essential to regulate insect molting, metamorphosis and reproduction. Like other steroid hormones, the accurate fluctuation of ecdysteroid titer in insects is synergistically regulated by its biosynthesis and degradation. Using the fruit fly and domesticated silkworm as experimental models, we aim at elucidating the molecular mechanism to address the timing of the steroid hormone pulse.
Courses
Developmental Biology, Genetics
Molecular Evolution
Major achievement
- First author & Corresponding author
（1） Cao LF#, Dai ZJ#, Tan HW#, Zheng HQ, Wang Y, Chen J, Kuang HO, Chong RA, Han MJ, Hu FL, Sun W*, Sun C* and Zhang Z*. (2023). Population structure, demographic history, and adaptation of giant honeybees in China revealed by population genomic data. Genome Biology and Evolution 15(3)
（2） Wang Y, Du TY, Li AN, Qiao L, Zhang Z* and Sun W* (2022). Establishment and application of a silkworm CRISPR/Cas9 tool for conditionally manipulating gene disruption in the epidermis. Insect Biochemistry and Molecular Biology 151:103861
（3） Wang Y, Zou HB, Lai J, Zhang Z* and Sun W* (2022). The miR-282-5p regulates larval moulting process by targeting chitinase 5 in Bombyx mori. Insect Molecular Biology 31:190–201
（4） Dai ZJ, Sun BY, Wang Y, Zhang Z and Sun W* (2022). Identification of genes involved in resistance to high exogenous 20-Hydroxyecdysone in Spodoptera litura. Insects 13: 297
（5） Duan HT, Yang X, Bu ZY, Li XY, Zhang Z and Sun W* (2020). Identification and characterization of genes involved in ecdysteroid esterification pathway contributing to the high 20-hydroxyecdysone resistance of Helicoverpa armigera. Frontiers in Physiology 11 :508
（6） Wang CF, Zhang Z*, Sun W* (2018). Ecdysone oxidase and 3-dehydroecdysone-3β-reductase contribute to the synthesis of ecdysone during early embryonic development of the silkworm. International Journal of Biological Sciences 14:1472-1482
（7） Sun W*, Wang CF, Zhang Z (2017). Transcription factor E74A affects the ecdysone titer by regulating the expression of the EO gene in the silkworm, Bomby mori. BBA-General Subjects 1861:551–558
（8） Sun W, Shen YH, Zhou LX, Zhang Z* (2016). Ecdysone titer determined by 3DE-3beta-reductase enhances the immune response in the silkworm. Journal of Immunology 196:1646-1654
（9） Sun W, Zhao XW and Zhang Z*. (2015) Identification and evolution of the orphan genes in the domestic silkworm, Bombyx mori. FEBS Letters 589: 2731–2738
（10） Sun W, Shen YH, Han MJ, Cao YF and Zhang Z*. (2014) An adaptive transposable element insertion in the regulatory region of the EO gene in the domesticated silkworm, Bombyx mori. Molecular Biology and Evolution 31:3302-3313
（11） Sun W, Shen YH, Qi DW, Xiang ZH and Zhang Z*. (2012) Molecular cloning and characterization of ecdysone oxidase and 3-dehydroecdysone-3α-reductase involved in the ecdysone inactivation pathway of silkworm, Bombyx mori. International Journal of Biological Sciences 8:125-138
（12） Sun W, Shen YH, Yang WJ, Cao YF, Xiang ZH and Zhang Z*. (2012) Expansion of the silkworm GMC oxidoreductase genes is associated with immunity. Insect Biochemistry and Molecular Biology 42:935-945
（13） Sun W, Yu HS, Shen YH, Banno Y, Xiang ZH and Zhang Z*. (2012) Phylogeny and evolutionary history of the silkworm. Science China Life Sciences 55:483-496
- Coauthor
（1） Li XW, Liu Q, Bi HL, Wang YH, Xu X, Sun W, Zhang Z* and Huang YP*. (2022). piggyBac-based transgenic RNAi of serine protease 2 results in male sterility in Hyphantria cunea. Insect Biochemistry and Molecular Biology 143:103726
（2） Kamiyama T, Sun W, Tani N, Nakamura A and Niwa R*. (2020) Poly(A) binding protein is required for nuclear localization of the ecdysteroidogenic transcription factor molting defective in the prothoracic gland of Drosophila melanogaster. Frontiers in Genetics. 11:636
（3） Dai ZJ, Sun W and Zhang Z*. (2018) Comparative analysis of iTRAQ-based proteomes for cocoons between the domestic silkworm (Bombyx mori) and wild silkworm (Bombyx mandarina). Journal of Proteomics 192: 366-373
（4） Zhang Q, Sun W, Sun BY, Xiao Y and Zhang Z*. (2017) The dynamic landscape of gene regulation during Bombyx mori oogenesis. BMC Genomics 18:714
（5） Yu XB, Shen YH, Cui QM, Chen Y, Sun W, Huang XZ* and Zhu Y. (2017) Silkworm (Bombyx mori) has the capability to accumulate C20 and C22 polyunsaturated fatty acids. European Journal of Lipid Science and Technology. 120: 1700268
（6） Fu P, Sun W, Zhang Z*. (2016) Molecular cloning, expression and characterization of acylpeptide hydrolase in the silkworm, Bombyx mori. Gene 580:8-16
（7） Zhao Q, Han MJ, Sun W and Zhang Z*. (2014) Copy number variations among silkworms. BMC Genomics 15:251
（8） Guo Y, Shen YH, Sun W, Kishino H, Xiang ZH and Zhang Z*. (2011). Nucleotide diversity and selection signature in the domesticated silkworm, Bombyx mori, and wild silkworm, Bombyx mandarina. Journal of Insect Science 11:155
Contact information
sunwei077@cqu.edu.cn
